Abstract
Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).
MeSH terms
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Benzopyrans / chemical synthesis
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Benzopyrans / chemistry*
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Dopamine Agonists / chemical synthesis
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Dopamine Agonists / chemistry*
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Models, Structural
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Receptors, Dopamine D2 / administration & dosage
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Receptors, Dopamine D2 / chemistry*
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Structure-Activity Relationship
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Templates, Genetic
Substances
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2-(N-benzylaminomethyl)-7-hydroxybenzopyran
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Benzopyrans
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Dopamine Agonists
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Receptors, Dopamine D2